Hormones and Breast Cancer.
Abstract
This grant consisted of 4 separate projects; Projects 1 and 4 aimed at assessing the association between lifestyle factors (exogenous hormone use) and breast cancer. The other two projects aimed at elucidating the role of estrogen metabolism in breast cancer development (Project 2) and the association between female hormones and mammographic densities, a possible intermediate endpoint for breast cancer (Project 3). Oral contraceptive use was not found to explain the increase in breast cancer risk that Asian migrants experience the first decade after they migrate to the US (Project 1). However, oral contraceptive use at a young age was associated with early onset breast cancer in young women (aged 35 or younger), while recent use appeared to be a more important risk factor in middle aged women (aged 36-4%) (Project 4). Results from Project 2 suggest that the ratio of the two urinary estrogen metabolites 2-hydroxyestrone and 1 6a-hydroxyestrone does not differ between postmenopausal breast cases and controls or between premenopausal women at 'high' and 'normal' risk of breast cancer. Project 3 suggested that reducing serum-levels of hormones reduced the amount of mammographic densities. The results from the last project may prove useful for cancer prevention studies.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 1997
- Accession Number
- ADB234453
Entities
People
- Giske Ursin
Organizations
- University of Southern California