Lewis Y Antigen as a Target for Breast Cancer Therapy
Abstract
The Lewis Y antigen is a breast cancer associated carbohydrate antigen. The basis of the current program is to utilize structural information for Lewis Y-antibody interactions to develop novel immunotherapeutics for breast cancer treatment. It is postulated that the Lewis Y determinant on human breast adenocarcinoma cells is of key importance since it mediates internalization and lethal function of Lewis Y specific MAb. To develop such immunotherapeutics, we have established the molecular recognition properties of several anti-Lewis antibodies for Lewis Y, we have established that peptide mimotopes of adenocarcinoma associated carbohydrate forms that include Lewis Y may function as a breast cancer vaccine, and have established that a molecular basis for such mimicry.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 1997
- Accession Number
- ADB235860
Entities
People
- Thomas Kieber-emmonds
Organizations
- University of Pennsylvania