Regulation of Breast Cancer Cell Repression and Differentiation by ErbB2 Ligand.

Abstract

This proposal has addressed the action of Heregulin family members on breast cancer cells. Three projects have been undertaken. Project one studied the activities of Heregulin 1 in altering the phenotype of human cancer cells growing in culture. Project two identified a new member of the Heregulin family NRG-3 and showed that it is expressed in human cancer and can alter the growth of human cancer cells. Project three was designed to address the importance of cdc42, rac and rho in growth signaling generated by erbB family signalling.

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Document Details

Document Type
Technical Report
Publication Date
Mar 01, 1998
Accession Number
ADB236753

Entities

People

  • Ritcher C. King

Organizations

  • Georgetown University

Tags

DTIC Thesaurus Topics

  • Amino Acids
  • Biomedical Research
  • Breast Cancer
  • Cell Line
  • Cell Membrane
  • Cell Movement
  • Cell Physiological Processes
  • Cells
  • Cellular Structures
  • Chemistry
  • Cytoskeleton
  • Governments
  • Medical Personnel
  • Neoplasms
  • Peptide Growth Factors
  • Proteins

Readers

  • Molecular Biology and Genetics