Roles of ER, Src-1, and CBP Phosphorylation in Estrogen Receptor-Regulated Gene Expression

Abstract

Breast cancer patients who possess cancers that are estrogen-dependent usually respond well initially to the antiestrogen, tamoxifen. However, the cancer subsequently becomes resistant to tamoxifen, possibly through increases in cAMP and protein kinase A activity which have been associated with the conversion of the tamoxifen metabolite, 4-hydroxytamoxifen (4HT), into an estrogen receptor agonist. Tamoxifen resistance may also occur through cellular alterations in the balance of steroid receptor coactivators and corepressors. This report describes a recently identified coactivator named E6-associated protein (E6-AP) which is a novel dual function protein that also subserves an independent function in the ubiquitin-proteasome protein degradation pathway.

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Document Details

Document Type
Technical Report
Publication Date
Jun 01, 1998
Accession Number
ADB237451

Entities

People

  • David M. Lonard

Organizations

  • Baylor College of Medicine

Tags

DTIC Thesaurus Topics

  • Acids
  • Amino Acids
  • Androgen Receptors
  • Biomedical Research
  • Breast Cancer
  • Cell Line
  • Chemistry
  • Degradation
  • Estrogens
  • Gene Expression
  • Hormones
  • Inhibitors
  • Mammary Glands
  • Materials
  • Neoplasms
  • Proteins
  • Resistance

Fields of Study

  • Biology

Readers

  • Breast cancer cell signaling and growth regulation.