Novel and Selective Inactivators for Matrix Metalloproteases Involved in Breast Cancer Metastasis
Abstract
Matrix metalloproteases (MMPs) are endopeptidases with a diverse set of physiological and pathological functions. Two of these proteases, MMP-2 and MMP-9, also known as gelatinases A and B, respectively, have been implicated in breast tumor metastasis. This research endeavors to prepare the first mechanism-based inactivators for these enzymes, molecules which are expected to show high selectivity in inactivation of the targeted enzymes. Toward this goal, six such putative inactivators were designed and synthesized in the Mobashery laboratory. Initial characterization with the enzyme indicated that three of these molecules showed the desired inactivating trait, but they exhibited relatively low affinities for the gelatinases. Work in on-going in the design of derivatives of higher affinity.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 1998
- Accession Number
- ADB240225
Entities
People
- Shahriar Mobashery
Organizations
- Wayne State University