Novel Approaches to Preventing Urinary Tract Infection in Women
Abstract
The overall purpose of this project is to investigate interactions between bacteria which commonly cause urinary tract infection (UTI) and their cognate host cell receptors in the vaginal and bladder epithelium in order to design novel, non-antibiotic methods for preventing UTIs. The project is focused on studying the two most common uropathogens causing UTI in young women, Escherichia coli and Staphylococcus saprophyticus, as well as their interactions with glycosphingolipids (GSLs) on the cell surface of the bladder and vagina. In the first two years of this project, we will define the key GSLs on the eukaryotic cell surface that uropathogenic bacteria use for attachment and then in the last two years, we will take advantage of new biochemical techniques using carbohydrate mimetics to design UTI prevention methods that avoid the induction of antimicrobial resistance. This report describes progress made in the second of four years of this grant.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 1998
- Accession Number
- ADB243196
Entities
People
- Ann E Stapleton
Organizations
- University of Washington