A Mouse Model for the Cloning of a Tumor Suppressor Gene Mutated in Sporadic Breast Cancer
Abstract
Wnt/ wingless growth factors cause mammary tumors when overexpressed, and have many developmental functions. Yet despite extensive studies on the Wnt ligands, and the putative pathway components, little Is known about the reception mechanisms of signaling by these growth factors. A candidate Wnt receptor has been isolated using the yeast two-hybrid system. This protein has been shown to specifically bind four Wnt ligands. Truncated receptor forms, when misexpressed In Drosophila , lead to wingless loss of function phenotypes, strengthening its legitimacy as a Wnt receptor. The study's long-term objectives is to further characterize and functionally test this gene product. This will involve studies in both mouse and Drosophila, employing both ectopic expression studies and null mutation analysis. The proposed research should verify and elaborate the protein's role in Wnt / wingless signal transduction as it pertains to development and tumorigenesis.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 1998
- Accession Number
- ADB244256
Entities
People
- Martin J. Shea
Organizations
- Baylor College of Medicine