Risk Factors for Chorioamnion Infection and Adverse Pregnancy Outcome Among Active-Duty Military women and Dependent Women
Abstract
Cervicovaginal ureaplasmal infection alone is not predictive of preterm birth. Only a subpopulation of women infected in the lower genital tract are at risk for chorioamnion invasion and premature birth. The major goal of the proposed study is to identify microbiologic factors that predispose to and/or predict chorioamnion invasion and premature birth. This study will determine if the presence of bacterial vaginosis (BV) is a risk factor for ureaplasmal invasion of the chorioamnion. 3,464 women have been enrolled to date. Vaginal cultures from all of these women have been assessed for Ureaplasma urealyticum (UU) colonization and gram stains have been assessed for BV. Data sheets from 2,205 women (prenatal visit) have been scanned and the data analyzed. Prenatal screens yield 1176/2190 or 54% culturally positive for UU and 384/2,101 or 18.3% of the gram stains are positive for BV. At delivery (388 women meeting study criteria for placental cultures including multiple births), the isolation rate of UU from the vagina is 53% regardless of delivery route. The isolation rate of UU from placental tissues is 9% from Cesarean section (C-section) deliveries and 15% from vaginal deliveries. The isolation rate of UU from amniotic fluid is 18.5% and from infant's nasal passages is 14% from C-section deliveries and 27% from vaginal deliveries. Gram stains for BV assessment at delivery is 17.9%.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 1998
- Accession Number
- ADB244626
Entities
People
- Gail H. Cassell
Organizations
- University of Alabama