Non-Invasive Determination of Breast Cancer Oxygen Tension by F-19 NMR and Breast Cancer Physiology in Response to Radiotherapy.
Abstract
It has been shown that the efficacy of radiotherapy, chemotherapy and photodynamic therapy are influenced by tumor oxygenation, and hypoxic tumors are refractory. Many techniques for monitoring pO2 have been developed. Most, however, are invasive. F-19 MRI of hexafluorobenzene (HFB), based on PBSR-EPI, provides an alternative non-invasive technique to monitor pO2. Implementation of this techniques, however, requires a high quality double-tuned (H-1 - F-19) whole body resonator in order to minimize preparation time and prevent accidental death of rat. Two resonators, one being a double-tuned whole body birdcage resonator and another one slotted tube resonator, have been constructed and tested. Laboratory bench testing and phantom imaging indicated that the birdcage resonator's B1 fields are somewhat heterogenous across usable volume of the resonator for both modes and the slotted tube resonator has high Q values and short 90 degree pulse width, which results in improved sensitivity. The B1 field was found to excellent for H-1 resonance and resonably good for F-19 resonance.
Document Details
- Document Type
- Technical Report
- Publication Date
- Aug 01, 1998
- Accession Number
- ADB244697
Entities
People
- Yulin Song
Organizations
- University of Texas Southwestern Medical Center