NMR Reconstructive Elasticity Imaging of Breast: Surrogate Remote Palpation Using Quantitative 3-D Displacement
Abstract
The goal of this research program is to develop a sensitive diagnostic technique based on quantitative elasticity imaging permitting surrogate palpation of deep lying breast lesions. The remote measurement of elasticity in breast tissues may provide unique information which could increase detection and/or characterization of potentially malignant masses not accessible to manual palpation. The primary technical objective of this study is to refine and test a novel MRI method for the acquisition of high resolution 3-dimensional spatial displacement data through the imaged object for quantitative estimation of internal strain and elastic modulus. Proof-of-concept of the proposed 3D displacement-encoding, stimulated echo technique has been completed and recently published using two-dimensional test objects. Design, fabrication, and refinement of an MRI pulse-sequence controlled, pneumatic deformation device is now complete. Initial tests confirm this device provides highly reproducible deformations as required by the method. Stable phantom materials and fabrication procedures have been determined for production of test objects. Extension of elasticity reconstruction and boundary detection algorithms to accommodate dimensionality of the MRI data are underway, with initial 3D-phantom tests planned for the first quarter of project year #2.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 1998
- Accession Number
- ADB244931
Entities
People
- Thomas L. Chenevert
Organizations
- University of Michigan