Fluorescence Optic Fiber Stereotactic Needle Ratiometer for Breast Tumor Diagnosis.
Abstract
A optical fiber needle based CD-ratiometer using native spectroscopic differences between diseased and normal tissues, has been designed, assembled, and tested for real time evaluation and diagnosis of breast tumor in vivo. A key point of the research project is using an optical fiber needle as a probe to deliver the excitation light to a tumor and collect the fluorescence from that region. The probe, with a small diameter of about 300 micrometers, can penetrate through the organ and interrogate tumor. Cancerous, benign/normal breast tissues have been measured and distinguished by the CD-ratiometer in vitro. Simulated measurements of a tumor inside normal tissue were performed using layered samples. Multiple wavelengths have been introduced to the optic fiber needle based CD-ratiometer for increased capability to separate fat from cancer. The measurement results have indicated that the CD-ratiometer can identify different tissue types by reading fluorescence intensity ratios at specified wavelength pairs. This research demonstrates the technological and commercial potentials of the optic fiber needle based CD-ratiometer for in situ spectroscopic analysis to reduce or replace breast biopsy.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 1998
- Accession Number
- ADB246577
Entities
People
- Alvin Katz
- Guichen Tang
- Robert Alfano