Lewis Y Antigen as a Target for Breast Cancer Therapy
Abstract
The Lewis Y antigen is a breast cancer associated carbohydrate antigen. The basis of the program was to establish and utilize structural information for Lewis Y-antibody interactions to develop novel immunotherapeutics for breast cancer treatment. It is postulated that the Lewis Y determinant on human breast adenocarcinoma cells is of key Importance since it mediates internalization and lethal function of Lewis Y specific MAb. During the course of the funding period we have: (1) established the molecular recognition properties of several anti-Lewis antibodies for Lewis Y, (2) established that peptide mimotopes of adenocarcinoma associated carbohydrate forms that include Lewis Y may function as a breast cancer vaccine, (3) established the molecular basis for such mimicry, and (4) have constructed a humanized single chain Fv form of a potent anti-Lewis Y antibody which is being further developed as a bispecific antibody.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 1998
- Accession Number
- ADB247801
Entities
People
- Thomas Kieber-emmons
Organizations
- University of Pennsylvania