Role of the Microphage Growth Factor, Colony Stimulating Factor-1, in the Etiopathogenesis of Breast Cancer
Abstract
Over-expression of the macrophage growth factor, colony stimulating factor-1 (CSF- 1) and its receptor, the cfms proto-oncogene product, is associated with progression of breast cancers and is correlated into poor prognosis. The recruitment of macrophages to tumors is also correlated with poor prognosis. It has been proposed that these macrophages secrete angiogenic factors and matrix remodeling activities that facilitate tumor growth and metatasis. Since CSF-l is the major growth factor for macrophages, we hypothesized that tumor synthesized CSF-l, in addition to possible autocrine roles, also promotes recruitment of tumor associated macrophages and through this mechanism enhances tumor progression. To test this, we have crossed a CSF-1 null mutation onto mice that have an increased susceptibility to mammary gland cancer. Initial results indicate that the absence of CSF-1 significantly reduces the incidence and progression of mammary gland tumors. This reduction in tumor incidence is correlated with a relative absence of macrophages in the tumors. Experiments are underway to manipulate CSF-1 signaling and re- introduce CSF-1 into the tumor to determine the action of CSF-1 and test the hypothesis that its mode of action is through the macrophages in the tumor.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 1998
- Accession Number
- ADB248345
Entities
People
- Jeffrey W. Pollard
Organizations
- Albert Einstein College of Medicine