Inhibition of Mitochondrial Estrogen Metabolism as a Possible Mechanism of Breast Cancer Prevention
Abstract
Breast cancer is the second leading cause of cancer-related deaths for women. Estrogen metabolism as well as mitochondrial alterations are strongly associated with cancer. We propose that the mitochondrial metabolism of estrogens play a major role in the induction of cancer. We have hypothesized that DES is metabolized by the mitochondria to DES quinone. We have further proposed that diallyl sulfide (DAS), a component of garlic, will inhibit the metabolism of DES. To test the hypotheses we isolated mitochondria, microsomes, and nuclei from the breast tissue of female ACI rats. UV analysis revealed that all three organelles catalyzed the oxidation and reduction of DES. DAS also inhibited these reactions by 50%. These results were confirmed by HPLC analysis. These results suggest that metabolism of estrogens may plays a critical role in estrogen induced breast cancer. DAS and similar chemicals may inhibit the formation of breast cancer by inhibiting this metabolism. This study provides a rationale for more advanced studies on DAS and similar chemicals on the prevention of breast cancer.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 1999
- Accession Number
- ADB248605
Entities
People
- Ronald D. Thomas
Organizations
- Florida A&M University