Biological Markers of Environmental Carcinogens in Breast Cancer
Abstract
This ongoing case-control study is being conducted at the Columbia Presbyterian Medical Center (CPMC) and is investigating whether exposures to polycyclic aromatic hydrocarbons (PAH) and heterocyclic aminos (HA), are associated with breast cancer. The study is designed to enroll 100 cases and 100 benign breast disease (lBBD) controls from whom blood, biopsy tissue and questionnaire data are collected and 100 healthy controls from whom blood and questionnaire data are collected. The study is utilizing biomarkers (PAM-, MA-, and smoking related-DNA adducts) as measures of exposure and p53 mutations as a biomarker of pre-clinical effects. Patient recruitment has been completed with 119 cases 107 BBD controls and 141 healthy controls enrolled. Laboratory assays for p53 in tissue sections and PAM-DNA adducts in white blood cells and tissue samples have been completed. Additionally, the study population has been analyzed for the GSTM I genotype. Descriptive statistical analyses of the data are complete and we have begun analyzing the relationship between case-control status and biomarkers. Preliminary analyses show that after control for age, etlinicity, breast feeding, age at menarche, parity, smoking status, ETS exposure, and charred food consumption elevated tissue levels of PAM-DNA adducts are associated with breast cancer case-control status (OR =2.7, p=O.O2).
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 1998
- Accession Number
- ADB248851
Entities
People
- Frederica P. Perera
Organizations
- Columbia University