Magnetic Resonance Spectroscopy: An Objective Modality to Identify the Pathology of Breast Neoplasms
Abstract
Proton MRS on FNA distinguishes benign breast lesions from invasive cancer with a sensitivity and specificity of 95% and 96%, respectively. Carcinoma in situ specimens are ranked by proton MRS as benign or malignant. This ranking is not explained by standard histopathological criteria, suggesting MRS is reporting on differences which are not morphologically manifest. FNA MR spectra with signal to noise ratios (SNR)>25 are required to ensure a correlation of MRS and histopathological data with a high sensitivity and specificity when visual inspection methods alone are employed. Computerised Consensus Diagnosis (CCD), however, distinguishes benign and malignant lesions with high sensitivity and specificity for FNA spectra including those with SNR<25. CCD is also able to predict the presence or absence of vascular invasion and lymph node involvement for patients with invasive breast lesions. Two dimensional MRS fails to discriminate between breast tissues (due to large lipid contribution to the spectra) or breast FNAs (due to inadequate signal to noise). Proton MRS on FNA and Magic Angle Spinning (MAS) MRS detects metastatic disease in axillary lymph nodes from breast cancer patients.
Document Details
- Document Type
- Technical Report
- Publication Date
- May 01, 1999
- Accession Number
- ADB249656
Entities
People
- Caroyln Mountford
Organizations
- University of Sydney