Effects of Diet High in Palmitoleic Acid on Serum Lipid Levels and Metabolism
Abstract
A randomized crossover feeding study with a macadamia nut and oil based high monounsaturated fat diet (HIMUFA) and a typical American diet high in saturated fat (HISAT) was conducted on 27 healthy men and women aged 20 to 52. Fatty acid profiles were HIMUFA: 22% MUFA, 9% SEA; HISAT: 11% MUFA, 20% SFA. Each diet was consumed for 8 weeks with a 2-month wash-out. Fasting plasma lipids and lipoprotein subclasses by using NMR or chemical analysis were measured on week 5 and the last two consecutive days of week 8 in each diet period. Isoenergenic substitution with 11% Kcal MUFA for SEA significantly reduced plasma total cholesterol, LDL, HDL, VLDL and TG (in NMR). A small but significant reduction in both LDL and HDL particle size in the HIMUFA diet compared to the HISAT diet. These were due to the reductions in larger particles- L3, and HDL2 (H5, H4). LDL particle concentrations in parallel with LDL levels were significantly reduced in the HIMUFA diet. The cholesterol lowering effects in total cholesterol and LDL of the HIMUFA diet are very prominent. Macadamia nut based MUFA can be a good alternative for SEA in the diet to lower CHD risks. Further investigations are warranted to evaluate the long-term beneficial effects of HIMUFA on CVD risk.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 2000
- Accession Number
- ADB255338
Entities
People
- Jesse D. Curb
Organizations
- University of Hawaiʻi at Mānoa