Risk Factors for Chorioamnion Infection and Adverse Pregnancy Outcome Among Active-Duty Military Women and Dependent Women
Abstract
Cervicovaginal ureaplasmal infection alone is not predictive of preterm birth. Only a subpopulation of women infected in the lower genital tract are at risk for chorioamnion invasion and premature birth. The major goal of the proposed study is to identify microbiologic factors that predispose to and/or predict chorioamnion invasion and premature birth. This study will determine if the presence of bacterial vaginosis (BV) is a risk factor for ureaplasmal invasion of the chorioamnion. 4,312 women have been enrolled to date, Vaginal cultures from all of these women have been assessed for Ureaplasma urealyticum (UU) colonization and a subset of gram stains have been assessed for BV. Prenatal screens yield 2,497/4,193 or 60% culturally positive for UU and 48612,700 or 18% of the gram stains are positive for BV. At delivery, (705 women meeting study criteria for placental cultures including multiple births), the isolation rate of UU from the vagina is 61% regardless of delivery route. The isolation rate of UU from placental tissues is 14%. The rate of BV at delivery is approximately 18%. The correlation of this data may help us better understand adverse pregnancy outcome including preterm birth as it relates to infection of the chorioamnion.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 1999
- Accession Number
- ADB256677
Entities
People
- Gail H. Cassell
Organizations
- University of Alabama