Identification of Prostate Specific Antigens for Immunotherapy Vaccines
Abstract
The activation of immune T lymphocytes that recognize and kill prostate cancer cells is an area of intense investigation. Conceptually, the activation of such cells could lead to elimination of metastatic disease. However, in practice the ability to activate appropriately targeted T lymphocytes and sustain the activation state of the T cells in a manner sufficient to eliminate tumors has been problematic. One important issue is the identification of appropriate antigens for targeting the immune response. Studies have been initiated to identify unique prostate antigens using A2 transgenic mice. Initial immunization studies using dendritic cells pulsed with RNA from prostate tumor cell lines shows the utility of the approach. A molecular subtraction technique is underdevelopment that will provide enrichment of prostate antigens prior to immunization. Once T cell lines are isolated, they will be used to identify the antigen.
Document Details
- Document Type
- Technical Report
- Publication Date
- Aug 01, 1999
- Accession Number
- ADB256683
Entities
People
- Timothy L Ratliff
Organizations
- University of Iowa