The Roles of Bone Morphogenetic Protein Signal Transduction in Prostate Carcinogensis

Abstract

Our understanding of the molecular genetic mechanisms of prostate carcinogenesis is still primitive. Due to this, effective preventive and therapeutic approaches to this prevalent disease have not been obtained yet. Our research goal is to use mouse molecular genetic approaches to examine the potential roles of Bone Morphogenetic Protein (BMP) signaling pathway in prostate epithelial cell growth and carcinogenesis. To accomplish this, we have designed a potent artificial prostate-specific promoter to drive constitutively active and dominant negative BMP receptors and constitutively active SMAD 1 (a down stream signaling protein of BMP family) in the mouse. The major work of DNA constructs has been finished and transgenic mice will soon be generated for further characterization.

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Document Details

Document Type
Technical Report
Publication Date
Aug 01, 1999
Accession Number
ADB256789

Entities

People

  • Guang-quan Zhao

Organizations

  • University of Missouri

Tags

DTIC Thesaurus Topics

  • Abstracts
  • Biomedical Research
  • Cell Physiological Processes
  • Cells
  • Computer Programs
  • Contractors
  • Diseases And Disorders
  • Epithelial Cells
  • Gene Expression
  • Government (Foreign)
  • Government Procurement
  • Governments
  • Laboratory Animals
  • Materials
  • Neoplasms
  • Peptide Growth Factors
  • Prostate Cancer

Fields of Study

  • Biology
  • Medicine

Readers

  • Immunology and Pathology
  • Molecular Biology and Genetics
  • Molecular and genetic basis of cancer.

Technology Areas

  • Biotechnology