Potential Prognostic Markers for Human Prostate Cancer
Abstract
The goal of this project is identify molecules that may be useful as predictive markers for human prostate cancer and to develop these molecules for use in clinically relevant tests that can predict outcome and disease course in prostate cancer patients. Our initial work has been focused on thymosin beta 15 (TB15), a molecule found in mid to high-grade prostate cancers. Our current results indicate that thymosin beta 15 is differentially expressed in invasive and in metastatic tumors but is less frequently expressed in non-invasive tumors. Expression of thymosin beta 15 at the time of diagnosis correlates with subsequent PSA failure, tumor recurrence, metastasis and mortality. We have also developed an ELISA for thymosin beta 15 and have used this test to detect the protein in the urine of prostate cancer patients. We believe that thymosin beta 15 along with other prognostic markers currently being developed could be useful in predicting outcomes and in choosing appropriate treatment strategies in prostate cancer patients.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 1999
- Accession Number
- ADB257222
Entities
People
- Bruce R. Zetter