Cellular and Molecular Roles of the Akt Protein Kinase in Breast Carcinomas

Abstract

Deregulation of the activity of the serine/threonine kinase Akt is likely to play an important role in initiation and/or progression of breast carcinomas. The goal of our studies is to characterize the effector-mediated pathways used by Akt to promote cell survival and to trigger malignant transformation. We have used a yeast two-hybrid approach to identify proteins that interact with Akt. C21, one of the isolates recovered in the screen, interacts with Akt in vitro and is a substrate for the Akt kinase. C21 is a transcription factor. Thus, Akt may trigger malignant transformation and promote cell survival in part by altering gene expression.

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Document Details

Document Type
Technical Report
Publication Date
Jun 01, 1999
Accession Number
ADB257359

Entities

People

  • Anne B. Vojtek

Organizations

  • University of Michigan

Tags

DTIC Thesaurus Topics

  • Abstracts
  • Amino Acids
  • Biomedical Research
  • Breast Cancer
  • Cell Physiological Processes
  • Cells
  • Chemical Synthesis
  • Chemistry
  • Gene Expression
  • Materials
  • Molecules
  • Neoplasms
  • Neutral Amino Acids
  • Proteins
  • Substrates
  • Survival
  • Transcription Factors

Fields of Study

  • Biology

Readers

  • Molecular Biology and Genetics