Genetic and Dynamic Analysis of Murine Peak Bone Density

Abstract

During the second year of support, the major effort has focused on genetic analyses. We have completed the production of the (C57BL/6 x C3H/He)F2 and (C57BL/6 x CAST/Ei) F2 progenies for analyses of the femoral-bone mineral density (BMD) phenotype. We have completed the genotyping of 10% of the populations with highest and lowest BMD from each F2 cross. The genotyping data for B6C3H-F2 mice show significant association of BMD with genetic loci on Chromosomes 1, 4 (two loci), 18, and 13. The genotyping data for B6CAST-F2 mice show significant association of BMD with genetic loci on Chromosomes 1, 3, 5, 13, and 14. In addition, we have tested the 12 BXH recombinant inbred (RI) strains for femoral and lumbar vertebral BMD and compared the resultant strain distribution patterns with polymorphic loci mapped in published data bases.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 1998
Accession Number
ADB257455

Entities

People

  • Wesley G. Beamer

Tags

DTIC Thesaurus Topics

  • Body Weight
  • Bone And Bones
  • Bone Diseases
  • Bone Fractures
  • Cells
  • Chromosomes
  • Computer Programs
  • Genes
  • Genetic Phenomena
  • Genetic Structures
  • Genetics
  • Liquid Chromatography
  • Medical Personnel
  • Osteogenesis
  • Osteoporosis
  • Phenotypes
  • Spine

Fields of Study

  • Biology

Readers

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Technology Areas

  • Biotechnology