Control of Breast Tumor Cell Growth by Dietary Indoles

Abstract

Indole-3-carbinol (I3C) is a naturally occurring component of dietary vegetables and a promising cancer preventive agent, most notably against breast cancer. 13C markedly reduces the incidence of spontaneous and carcinogen-induced mammary tumors in rodents and exhibits potent growth inhibitory activity in human breast cancer cells. Although 13C has reached the stage of phase I clinical trials, little is known about the mechanism of its growth inhibitory effects in cancer cells. The purpose of this work is to establish the mechanism of action and to exploit the cancer preventive properties of 13C and related compounds.

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Document Details

Document Type
Technical Report
Publication Date
Sep 01, 1999
Accession Number
ADB257618

Entities

People

  • Leonard Bjeldanes

Organizations

  • University of California, Berkeley

Tags

DTIC Thesaurus Topics

  • Biomedical And Dental Materials
  • Breast Cancer
  • Cell Line
  • Cell Physiological Processes
  • Cells
  • Chemical Synthesis
  • Chemistry
  • Cultured Cells
  • Lymphocytes
  • Neoplasms
  • Polymeric Films
  • Proteins
  • Tumor Cell Line

Fields of Study

  • Medicine

Readers

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