Evaluation of Cycloogenase-2 as a Novel Target for Breast Cancer Prevention
Abstract
Cyclooxygenase (Cox) catalyzes the synthesis of prostaglandins and the intracellular production of mutagens from procarcinogens. Cox-2, the inducible form of cyclooxygenase, is expressed in a wide variety of human cancers, but its role in breast cancer has not been established. Our research is designed to test whether Cox-2 contributes to mammary cancer, using Wnt-1-1 as a model mammary oncogene. The role of Cox-2 in mammary tumorigenesis is being tested by evaluating the incidence of mammary hyperplasia and carcinoma formation in Wnt-1 transgenic (TG) mice of the following Cox-2 genotypes: (+1+), (+1-), and (-/-). Initial breeding programs to generate F1 mice for use in the final cross have been completed, and these mice are currently being crossed to produce offspring of the required test genotypes.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 2000
- Accession Number
- ADB258193
Entities
People
- Andrew J. Dannenberg
Organizations
- Weill Cornell Medicine