Molecular Regulation of Immune Recognition Molecule Expression by Breast Cancer Cells

Abstract

New strategies to improve the outcome of patients with metastatic breast cancer must address the issue of residual chemotherapy-resistant cells. Immunotherapy offers the potential of manipulating effector cells to generate an enhanced anti-tumor effect. From initial data demonstrating that natural killer (NK) cells require interleukin-2 (IL-2) in order to lyse breast cancer targets, we have now explored the mechanisms which mediate tumor killing.

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Document Details

Document Type
Technical Report
Publication Date
Sep 01, 1999
Accession Number
ADB258195

Entities

People

  • Linda J. Burns

Organizations

  • University of Minnesota

Tags

DTIC Thesaurus Topics

  • Biomedical Research
  • Blood
  • Breast Cancer
  • Cancer
  • Cell Physiological Processes
  • Cells
  • Chemistry
  • Chemotherapy
  • Governments
  • Lymphocytes
  • Molecules
  • Neoplasms
  • Peptide Growth Factors
  • Peptides
  • Proteins
  • Therapy
  • Vaccines

Fields of Study

  • Biology
  • Medicine

Readers

  • Immunology
  • Oncology (Cancer Research).

Technology Areas

  • Biotechnology
  • Biotechnology - Cancer Biotech