Apoptosis and Tumor Invasion in Breast Cancer

Abstract

The three aims of this research: Specific Aim 1: Characterize the ability of anti-estrogens to induce apoptosis and an invasive phenotype in a sub-population of cells in vitro. Specific Aim 2: Compare the sensitivity of the MCF-7(ae) (inv) sublines to other agents that induce apoptosis and determine if multiple agents can act synergistically to induce apoptosis. Specific Aim 3: To determine whether treatment with anti-estrogens or other apoptosis inducing reagents (such as vitamin D analogs) alters the rate and/or sites of metastasis and whether invasive cells generated by treatment with one reagent are sensitive to treatment with other reagents that induce cell death in vivo.

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Document Details

Document Type
Technical Report
Publication Date
Aug 01, 1999
Accession Number
ADB258196

Entities

People

  • Martin Tenniswood

Organizations

  • University of Notre Dame

Tags

DTIC Thesaurus Topics

  • Abstracts
  • Acquisition
  • Apoptosis
  • Biological Sciences
  • Biomedical Research
  • Breast Cancer
  • Cell Line
  • Cell Physiological Processes
  • Cells
  • Contractors
  • Gene Expression
  • Government Procurement
  • Governments
  • Indicator Dyes
  • Materials
  • Neoplasms
  • Tumor Cell Line

Fields of Study

  • Biology
  • Chemistry
  • Medicine

Readers

  • Oncology (Cancer Research).