Reversible Suppression of Menstruation with Antiprogestins

Abstract

Our goal is to develop a method for reversible suppression of menses through use of antiprogestins. In the current year we showed that treatment with low doses of the new generation antiprogestin, ZK 230 211 will block menses in rhesus macaques. Doses of ZK 230 211 that block menses also blocked ovulation, but these effects were reversible once treatment stopped. Studies on ovariectomized-hormone treated macaques defined a range of doses of ZK 230 211 from 0.005 mg/kg, which had minimal effects, to a full blockade of progesterone action at 0.032 mg/kg. Doses > 0.016 mg/kg blocked progesterone action and also inhibited the proliferative effects of estradiol, resulting in reduced endometrial mass and thickness. No untoward effects of ZK 230 211 were detected in the macaques. The inhibitory action of ZK 230 211 on the endometrium could be demonstrated with both systemic and local delivery of the compound and we showed that ZK 230 211 could be effectively administered with intrauterine devices (IUDs).

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 1999
Accession Number
ADB258545

Entities

People

  • Robert M. Brenner

Tags

DTIC Thesaurus Topics

  • Animals
  • Biomedical Research
  • Blood
  • Cells
  • Experimental Design
  • Government Procurement
  • Governments
  • Histological Techniques
  • Histology
  • Hormones
  • Menstrual Cycle
  • Menstruation
  • Ovulation
  • Progesterone
  • Reversible
  • Thickness
  • Urogenital System

Readers

  • Immunology
  • Toxicology/Environmental Toxicology
  • Women's Health and Cancer Risk Research: African American Women and Pregnancy Outcomes.