Centrosome Hypertrophy Induced by p53 Mutations Leads to Tumor Aneuploidy
Abstract
This research is designed to test the hypothesis that aneuploidy in some breast tumors is caused by centrosome abnormalities induced by alteration in p53 function. Specific mutations in p53 associated with breast cancer, aneuploidy, and centrosome abnormalities will be identified. To test the effects of specific p53 mutations on centrosomes, normal mammary epithelial cells will be transfected to over-express mutant p53 and then monitored for changes in ploidy and centrosome structure and function. It is expected that significant novel information will emerge from these studies.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 01, 1999
- Accession Number
- ADB258699
Entities
People
- Wilma L. Lingle