Targeted Gene Therapy for Breast Cancer
Abstract
Immunotherapy has proven to be safe and effective in targeting human cancers in a clinical setting. However, durable disease-free remissions have yet to be realized in the majority of treated patients. Unconjugated antibodies can be improved by the attachment of effector molecules to the cancer-specific antibody. Improvements in the design of antibody based therapeutics will require specific delivery of cytotoxic agents such as toxin molecules or toxin-encoding genes. Two monoclonal antibodies with selective binding to HER-2/neu overexpressing breast cancer cells have been miniaturized by fusing variable chain genes with the dimerization domain of the human Fc constant region.
Document Details
- Document Type
- Technical Report
- Publication Date
- Aug 01, 1999
- Accession Number
- ADB258706
Entities
People
- Jinha M. Park
- Michael Press
Organizations
- University of Southern California