The Role of the Phosphadityl Inositol 3' Kinase Coupled Signaling Pathways in Mammary Tumorigenesis

Abstract

The primary objective of this proposal is to elucidate the role of the phosphadityl inositol 3' kinase (PI-3' kinase) and its coupled downstream signaling pathways in the induction of mammary cancers. In particular, we have focused on the activation of the PI-3' kinase signaling pathway and the Akt/PKB serine kinase which is one of the immediate downstream targets of activated PI-3' kinase. To this end, we have derived separate transgenic strains which express activated versions of either PI-3' or Akt kinase under the transcriptional control of the mouse mammary tumor virus (MMTV) promoter. Preliminary phenotypic characterization of these strains revealed mammary epithelial specific expression of either activated PI-3' or Akt kinase resulted in the induction of low-grade mammary epithelial hyperplasias without the overt appearance of mammary tumors.

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Document Details

Document Type
Technical Report
Publication Date
Jul 01, 1999
Accession Number
ADB258947

Entities

People

  • William Muller

Organizations

  • McMaster University

Tags

DTIC Thesaurus Topics

  • Abstracts
  • Animals
  • Biomedical Research
  • Breast Cancer
  • Cell Physiological Processes
  • Cells
  • Chemical Compounds
  • Chemistry
  • Government Procurement
  • Governments
  • Mammary Glands
  • Materials
  • Molecules
  • Neoplasms
  • Sugar Alcohols
  • Tissues
  • Viruses

Fields of Study

  • Biology

Readers

  • Molecular Biology and Genetics