The Role of a First Intron Negative Regulatory Element in the Repression of EGFR Expression in Hormone-Dependent Breast Cancer

Abstract

Breast cancer progression from a hormone-dependent, anti-estrogen sensitive to a hormone independent, anti-estrogen insensitive phenotype involves the loss of estrogen receptor (ER) expression and the up-regulation of a number of growth factor receptors and/or their ligands, including the epidermal growth factor receptor (EGFR). EGFR has been demonstrated to be overexpressed in breast cancer and is inversely correlated with ER status in a majority of breast tumors. EGFR overexpression, independent of ER status, is associated with a more aggressive phenotype and predicts for poor response to endocrine therapy, suggesting that up-regulation of EGFR is involved in the progression to a more aggressive, hormone-independent phenotype.

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Document Details

Document Type
Technical Report
Publication Date
Aug 01, 1999
Accession Number
ADB259015

Entities

People

  • Melissa A. Wilson

Organizations

  • Georgetown University

Tags

DTIC Thesaurus Topics

  • Abstracts
  • Biomedical Research
  • Breast Cancer
  • Cell Line
  • Cells
  • Chemical Compounds
  • Chemistry
  • Estrogens
  • Gene Expression
  • Genetics
  • Governments
  • Growth Factors
  • Neoplasms
  • Phenotypes
  • Proteins
  • Regulations
  • Tumor Cell Line

Readers

  • Molecular Biology and Genetics