Design and Synthesis of New Breast Cancer Chemotherapeutic Agents
Abstract
This proposal is directed towards the development of new chemotherapeutic agents based on the mechanism of action of Taxol. The recent discovery of two other natural products, epothilone and discodermolide, that operate by the same unique mechanism of action as Taxol, i.e., microtubule stabilization, provides a unique opportunity for a collaborative approach using synthetic and computational studies for the elucidation of the pharmacophore common to these structurally dissimilar substances. Such an advance could lead to the development of a novel family of breast cancer chemotherapeutics. We describe herein the synthesis and biological evaluation of novel analogs of the potent antitumor agent epothilone. Our results indicate that these partial structures do not have sufficient similarity to the natural product for biological activity.
Document Details
- Document Type
- Technical Report
- Publication Date
- Aug 01, 1999
- Accession Number
- ADB259031
Entities
People
- Jeffrey D. Winkler
Organizations
- University of Pennsylvania