Immunobiological Aspects of erbB Receptors in Breast Cancer
Abstract
The purpose of our studies was to define basic features of receptor complex formation relevant to breast cancer. Our efforts are to determine the amino acid residues required to form a transforming receptor assembly so as to develop an understanding of a subset of human aggressive breast cancers characterized by erbB receptor ensembles. Moreover, knowledge of the role of the kinase containing endodomain of these receptors is desirable as therapeutic intervention of breast cancer becomes more oncoprotein specific. In addition, the activity of ligand-like molecules that modulate pl85 her2/neu receptor complex activity has been studied. We have defined principles of erbB receptor assembly and modulation by ligand.
Document Details
- Document Type
- Technical Report
- Publication Date
- Aug 01, 2000
- Accession Number
- ADB259877
Entities
People
- Mark Greene
Organizations
- University of Pennsylvania