The Essential Role of Protein Phosphatase-1 in Mitogenic Signaling and Breast Cancer

Abstract

There is growing evidence that protein dephosphorylation is as important as protein phosphorylation in cell proliferation. I am currently studying the role of protein phosphatase 1 (PP 1), a serine/threonine phosphatase, in mitogenic signaling and breast cancer progression. To accomplish this goal, the following objectives are being addressed: (1) Determination of the changes in expression and function of MAP kinase and PP1 isoforms in a diversity of breast cancer cells. (2) Using Xenopus oocytes, we are delineating the role of PP1 in the activation of the MAP kinase pathway. (3) Identification of regulatory proteins capable of binding to PP1 and modulating its function in mitogenic signaling by screening Xenopus and MCF-7 expression libraries. (4) Determination of the effect of PP1 regulatory proteins on its function in mitogenic signaling and growth regulation.

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Document Details

Document Type
Technical Report
Publication Date
Jul 01, 1999
Accession Number
ADB259894

Entities

People

  • Carey J. Oliver

Organizations

  • Duke University Hospital

Tags

DTIC Thesaurus Topics

  • Amino Acids
  • Biomedical Research
  • Breast Cancer
  • Carrier Proteins
  • Cell Line
  • Cell Physiological Processes
  • Cells
  • Chemistry
  • Genetic Structures
  • Government Procurement
  • Governments
  • Materials
  • Neutral Amino Acids
  • Phosphorylation
  • Proteins
  • Standards
  • Threonine

Fields of Study

  • Biology
  • Chemistry

Readers

  • Breast cancer cell signaling and growth regulation.