Elucidating the Role of cAbl and the Abi-Family of cAbl Target Proteins in Cancer Development and Progression

Abstract

Abl-interactor (Abi) proteins bind and are phosphorylated by the non-receptor tyrosine kinases Abl and Arg. Two Abi family genes, Abi-1 and Abi-2, have been identified. Abi proteins demonstrate properties consistent with a potential tumor suppressor function. We investigated the role of Abi- 1 and Abi-2 proteins and their interactions with c-Abl and c-Abl-derived oncogenes in normal development and tumorigenesis. Abi-1 and Abi-2 exhibit both unique and overlapping temporal-spatial patterns of expression during embryonic and post-natal mouse development. Abi-2 is enriched in regions of the central and peripheral nervous systems (CNS and PNS) pre- and post-natally. Abi-1 is also enriched in regions of the post-natal brain, but is not enriched in the pre-natal CNS and is absent from examined PNS structures. Abi proteins undergo changes in phosphorylation during development.

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Document Details

Document Type
Technical Report
Publication Date
Jul 01, 1999
Accession Number
ADB259953

Entities

People

  • Kevin D. Courtney

Organizations

  • Duke University Hospital

Tags

DTIC Thesaurus Topics

  • Brain
  • Breast Cancer
  • Cell Line
  • Cell Physiological Processes
  • Cells
  • Central Nervous System
  • Chemistry
  • Fibroblasts
  • Materials
  • Medical Personnel
  • Neoplasms
  • Nervous System
  • Proteins

Fields of Study

  • Biology

Readers

  • Allergy and Immunology.
  • Breast cancer cell signaling and growth regulation.