Development of Intraductal Technique for Breast Cancer Prevention, Diagnosis and Treatment (97 Breast)
Abstract
The purpose of this project was to develop a reliable, non-invasive technique to gain access to the lining of the milk ducts. In this contract we have devised a technique to reliably identify all of the ductal orifices and confirmed their anatomy in a normal woman using MRI to correlate the ductal orifices to the ducts. The second accomplishment was to demonstrate that we can reliably retrieve ductal epithelial cells as washings by cannulating a duct with a double lumen catheter. Finally, we confirmed the ability to identify a specific ductal orifice, cannulate it with the double lumen catheter and obtain washings in six women scheduled for surgery. This work has led to two patents and 510k approval of the catheter from the FDA. It is being developed by a venture-backed company, Pro.Duct Health Inc, and is in multicenter clinical trials leading to a commercial product in the spring of 2000. The catheter and procedure of ductal lavage will enable clinicians and researchers to non invasively and repeatedly sample the ductal epithelial cells in high risk women, opening the way for the identification of markers, and also provide the ability to monitor the success of chemoprevention techniques. In addition, the intraductal approach to the breast can be exploited for local application of ablative or gene therapy.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 1999
- Accession Number
- ADB259960
Entities
People
- Susan Love
Organizations
- University of California, Los Angeles