DNA Vaccination Against Metastatic Breast Cancer
Abstract
HER2/neu over-expression is found in 30-40% of breast cancer biopsy and is indicative of metastasis and poor prognosis. Although significant advances have been made in the treatment of breast cancer, once metastasis has occurred the possibility of a complete cure is unlikely. A vaccine targeting HER2/neu could have significant therapeutic and preventative application by controlling the growth and spread of highly aggressive HER2/neu+ cells. Gene vaccines, bacterial expression plasmids encoding the DNA sequence for antigens, represent a new approach to inducing strong anti-tumor immunity. Although gene vaccines have shown effectiveness in clinical trials, it is essential to demonstrate pre-clinical effectiveness for anti-tumor vaccines before clinical testing can begin.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 2000
- Accession Number
- ADB260153
Entities
People
- Lawrence B. Lachman
Organizations
- United States Army Medical Research and Development Command