Total Synthesis of Eleutherobin and Analogs and Study of Anti-Cancer Mechanism

Abstract

Eleutherobin is a marine natural product discovered in 1994. It serves as one of the most potent anti-cancer agents mimicking Taxol. The proposed research is focused on improving the total synthesis of eleutherobin, and based on that developing eleutherobin analogs for biological studies. A modified eleutherobin synthesis is being studied. Compared to the initial Synthesis, the new synthesis is designed to improve the stereoselectivity of key steps and shorten the sequence.

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Document Details

Document Type
Technical Report
Publication Date
May 01, 2000
Accession Number
ADB261339

Entities

People

  • Qiang Tan
  • Samuel Danishefsky

Organizations

  • Memorial Sloan Kettering Cancer Center

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  • Biomedical Research
  • Cancer
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Fields of Study

  • Chemistry

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