Targeting Prostate Vasculture
Abstract
In this application, we propose to identify pep tides that home to the vasculature of prostate. Pep tides capable of homing to the prostate vasculature may allow imaging of the prostate for diagnostic purposes. They will also make it possible to direct into the prostate treatments that can reduce the size of the prostate and, therefore, reduce the risk of developing prostate cancer. During the first year of this grant, we have identified a pep tide that homes specifically to mouse prostate tissue. We've determined, using the phage and peptide-biotin conjugates, that this peptide accumulates specifically in the prostate tissue after intravenous injection. Preliminary results from a phage overlay assay on human prostate tissue suggest that this peptide will home to human prostate vasculature. These results represent significant progress toward our goal of prostate imaging and targeting of therapies into the prostate.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 1999
- Accession Number
- ADB262079
Entities
People
- Erkki Ruoslahti
Organizations
- Sanford Burnham Prebys Medical Discovery Institute