Detection of Prostate Cancer Utilizing Monoclonal Antibody J591 and Intraoperative Beta and Gamma Cameras
Abstract
We have produced a monoclonal antibody that specifically binds to a prostate specific membrane antigen. This compound, called J591, has been labeled with radioactive isotopes In-Ill and Y-90. We have developed three novel cameras that are capable of efficiently detecting a wide variety of radioisotopes that emit gamma or beta rays. They are small and can enter the body during open surgery orendoscopic procedures to provide better images in a shorter time, and more importantly, in real time, while the surgery is proceeding. These include: a hand held beta camera, a flexible beta camera, and a hand-held gamma camera. The hypothesis of this project is that these novel cameras, applied during surgery on prostate cancer patients after being injected by radio labeled antibody J591, would detect small pieces of cancerous tissue that would otherwise remain undetected. We will examine this by first modifying the cameras for prostate surgery. A group of prostate cancer patients who are scheduled for surgery, will be injected with radio labeled J59l mAb. Then our cameras will be used during surgery to locate any involved lymph node, or tissues at the margins of the respected prostate that may be infiltrated by cancer. Also, we will use our flexible beta camera to locate the best site in transrectal biopsies. According to our plan, the first year was devoted to development of the novel instrumentation for detection of prostate tumors. This task was successfully completed, and we are currently testing the instruments in the laboratory and refining them before entering the clinical trials.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 1999
- Accession Number
- ADB262329
Entities
People
- Steven M. Larson
Organizations
- Memorial Sloan Kettering Cancer Center