Identification of Telomerase Components and Telomerase Regulating Factors in Yeast

Abstract

Telomeres, specialized structures at the ends of chromosomes, help maintain the stability of the genome and are essential for continued cell proliferation. The purpose of this research has been to understand the processes involved in maintaining the length and integrity of chromosome ends using the yeast S. cerevisiae as a model system. This work has helped to define three genetic pathways that are critical for telomere function and replication; one defined by the Ku complex, a second comprises telomerase and MREll, RAD5O, and XRS2, and the third identified by CDCl3 and STNl. Although chromosome ends must be functionally distinct from DNA double strand breaks, genes involved in DNA double-strand break repair were found to play critical roles in two of these genetic pathways for maintaining telomeres.

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Document Details

Document Type
Technical Report
Publication Date
Jul 01, 2000
Accession Number
ADB265236

Entities

People

  • Constance Nugent
  • Victoria Lundblad

Organizations

  • Baylor College of Medicine

Tags

DTIC Thesaurus Topics

  • Abstracts
  • Biomedical Research
  • Breast Cancer
  • Carrier Proteins
  • Cell Physiological Processes
  • Cells
  • Cellular Structures
  • Chemistry
  • Chromosome Structures
  • Eukaryotes
  • Fungi
  • Genetics
  • Medical Genetics
  • Medical Personnel
  • Neoplasms
  • Proteins
  • Students

Fields of Study

  • Biology

Readers

  • Housing Policy Studies in Military Families with Privatization and Telomerase Allowance Units, Multi-Family Housing, and Telomere Lengths.
  • Molecular Genetics

Technology Areas

  • Biotechnology