Measurements of Breast Tissue Optical Properties
Abstract
Near-infrared (NIR) optical spectroscopy demonstrates unique possibilities for non-invasively monitoring tissue physiology. A bedside-capable instrument, using low levels of non-ionizing NIR light delivered by a hand-held probe, measures both absorption and scattering properties of tissues. A diffusive model for photons traveling through large tissue volumes quantifies oxygenated and deoxygenated hemoglobin, water, and lipid by their absorption signatures. Cellular density, fat, and collagen content are evaluated from the measured light- scattering spectra. This quantitative functional information cannot be obtained with other non-invasive radiological techniques. The prototype instrument revealed physiological changes in breast consistent with age-dependent histological alterations in 28 healthy female volunteers. A preliminary in vivo measurement of the therapeutic efficacy of two chemotherapy agents on a tumor in a human subject is also presented.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2000
- Accession Number
- ADB265247
Entities
People
- Albert Cerussi
- Bruce Tromberg
Organizations
- Beckman Laser Institute