Cellular and Molecular Roles of the Akt Protein Kinase in Breast Carcinomas
Abstract
Akt is a serine/threonine kinase that has been implicated in the initiation and/or progression of breast cancers. In order to gain an understanding of how Akt promotes malignant transformation, we identified proteins that are regulated by phosphorylation by Akt, including a POU domain family transcription factor and the B-Raf serine/threonine kinase. Whereas Akt may upregulate gene expression through phosphorylation of the POU domain transcription factor, Akt negatively regulates B-Raf activity in vitro and in vivo by phosphorylating two residues in the amino-terminal regulatory domain of B-raf.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 01, 2000
- Accession Number
- ADB265810
Entities
People
- Anne Vojtek
Organizations
- University of Michigan