The Contributions of 8p Loss and 8p Gain to the Malignant Phenotype in Human Prostate Tumors
Abstract
The three specific aims of my project are: Specific Aim 1; transfect normal prostatic epithelium with the E6 and E7 genes of HPVl6 to produce immortalized cell lines, then genotype these cell lines to determine 8p and 8q status: retention of 8p sequences, loss of 8p sequences, or loss of 8p+gain of 8q sequences ISO(8Q); Specific Aim 2: determine whether loss of 8p sequences or loss of 8p+gain of 8q sequences is associated with expression of the transformed or invasive/metastatic phenotypes in the E6/E7 immortalized cells; Specific Aim 3 (Long Term Goals): isolate 8p-specific and 8q-specific genes that contribute to the transformed or invasivelmetastatic phenotype in E6/E7 immortalized cells.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 2000
- Accession Number
- ADB266235
Entities
People
- Rajiv Kant
Organizations
- University of Michigan