Genetic Epidemiology of in Situ Breast Cancer

Abstract

No study has reported the risk factors and cancer screening practices associated with a diagnosis of breast carcinoma in-situ (BCIS), across all categories of age and histology. The data are from a population-based case/control study which includes all female cases of BCIS diagnosed among residents of the state of Connecticut from 9/15/94 to 3/14/98 as well as a series of random-digit-dial (RDD) controls. Cases (n=1068) were between the ages of 20 and 79 years at time of diagnosis while controls (n=999) were frequency matched to the cases by five-year age intervals. Cases with ductal carcinoma in-situ (DCIS) were more likely than controls to be older at age of first full-term pregnancy and at menopause, to have had a previous breast biopsy as well as fewer full-term pregnancies. In addition, DCIS cases were more likely to report a family history of breast cancer particularly at a young age. With respect to cancer screening, DCIS cases were more likely than controls to have had at least' one screening mammogram and to be receiving yearly breast exams by a physician. Cases with lobular carcinoma in-situ (LCIS) were more likely than controls to be older at menopause, to have had at least one breast biopsy and yearly physician-performed breast exams. No association was found between oral contraceptive use or hormone replacement therapy (HRT) and BCIS risk nor was there an association seen between diagnosis and use of breast self examination (BSE). Screening was significantly associated with a number of breast cancer risk factors including race, family history, HRT use and a previous breast biopsy. The risk factors for BCIS are similar to many of those associated with invasive breast cancer. The diagnosis of BCIS is associated with the use of mammography and yearly physician-performed breast examinations but not with BSE.

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Document Details

Document Type
Technical Report
Publication Date
Dec 01, 2000
Accession Number
ADB267647

Entities

People

  • Elizabeth Claus

Organizations

  • Yale University

Tags

DTIC Thesaurus Topics

  • Biomedical Research
  • Breast Cancer
  • Cancer Screening
  • Carcinoma
  • Diseases And Disorders
  • Drug Therapy
  • Health
  • Health Services
  • Medical Personnel
  • Neoplasms
  • Personnel Management
  • Physicians
  • Public Health
  • Risk Factors
  • Statistical Analysis
  • Therapy
  • United States

Fields of Study

  • Medicine

Readers

  • Oncology and Biomarker-Based Cancer Detection.
  • Women's Health and Cancer Risk Research: African American Women and Pregnancy Outcomes.

Technology Areas

  • Biotechnology