The Molecular Mechanism of the Supra-Additive Response of Prostate Cancer to Androgen Ablation and Radiotherapy

Abstract

The investigation pursued here involved the characterization of the molecular changes induced by androgen deprivation (AD) and the potential for these changes to result in a supra-additive interaction with radiation (RT). Molecular markers were measured in human tissue samples, as well as LNCaP cells grown in vitro under different conditions. Another project that was to develop out of this work, but which ended up being accelerated because of promising results, was the radiosensitizing effect of gene therapy (GT) using adenoviral- p53 (Ad5-p53).

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Document Details

Document Type
Technical Report
Publication Date
Feb 01, 2001
Accession Number
ADB267652

Entities

People

  • Alan Pollack

Organizations

  • The University of Texas MD Anderson Cancer Center

Tags

DTIC Thesaurus Topics

  • Cell Physiological Processes
  • Chemistry
  • Health Services
  • Medical Personnel
  • Neoplasms
  • Oncology
  • Prostate Cancer
  • Radiation Oncology
  • Therapy
  • Three Dimensional

Readers

  • Geotechnical Engineering.
  • Molecular Genetics
  • Prostate Cancer Biology.

Technology Areas

  • Biotechnology
  • Biotechnology - Cancer Biotech