Visual Servoing for Optimization of Anticancer Drug Uptake in Human Breast Cancer Cells

Abstract

The purpose of this two-year IDEA proposal is to gather preliminary data that demonstrate the feasibility of a new class of in vitro drug response and chemosensitivity assays. Our objectives are to develop an instrument (a visual servoing optical microscope, or VSOM) in a stepwise fashion and gather preliminary data to aid future development of cell culture techniques and fluorescence assays. Our goal is to demonstrate the feasibility of using VSOM technology to analyze the heterogeneity and physiological characteristics of tumor cells from individual breast cancer patient biopsies. We believe that the VSOM will be extremely useful in developing new VSOM chemosensitivity fluorescence assays for a variety of breast cancer drugs. At the conclusion of this grant, we will have preliminary data that demonstrate the use of a VSOM doxorubicin chemosensitivity assay based on the dynamic physiological responses of single cells.

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Document Details

Document Type
Technical Report
Publication Date
Sep 01, 2000
Accession Number
ADB269253

Entities

People

  • Bahram Parvin
  • Daniel E. Callahan

Organizations

  • University of California, Berkeley

Tags

DTIC Thesaurus Topics

  • Breast Cancer
  • Cell Membrane
  • Cell Physiological Processes
  • Cells
  • Chemical Synthesis
  • Chemistry
  • Computational Science
  • Computer Programming
  • Computer Programs
  • Computer Science
  • Computer Vision
  • Computers
  • Culture Techniques
  • Data Mining
  • Health Services
  • Operating Systems
  • Pattern Recognition

Fields of Study

  • Medicine

Readers

  • Instructional Design and Training Evaluation.
  • Oncology (Cancer Research).