A Longitudinal Study of Bone Turnover, Menopause, Aging and Ethnicity as Risk Factors for Osteoporosis

Abstract

This four-year study is a cost-efficient and timely longitudinal study of bone turnover markers in an ethnically diverse sample of mid-aged women as they experience the menopause transition. Building on the multi-site Study of Women's Health Across the Nation (SWAN), funded by the National Institutes of Aging and Nursing Research at the National Institutes of Health, this study analyzed already collected and stored specimens of serum to measure bone formation (using an immunoradiometric assay of osteocalcin) and stored urine specimens to measure bone resorption (using urinary N-telopeptide of type I collagen) These two measures will be combined with data from SWAN on bone density (spine, hip and femoral neck), ovarian aging (endogenous sex hormones and menstrual bleeding), medications, medical history, social and psychological assessments, and life style factors (exercise, diet, smoking, body mass) to address five research aims. To date, all bone marker as says have been completed, analyses to address the research aims are presented in the attached report. Work is underway on the corresponding manuscripts.

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Document Details

Document Type
Technical Report
Publication Date
Apr 01, 2001
Accession Number
ADB269814

Entities

People

  • Sonja M. Mckinlay

Tags

DTIC Thesaurus Topics

  • African Americans
  • Biomedical Research
  • Bone Diseases
  • Bone Fractures
  • Contracts
  • Descriptive Analytics
  • Ethnic Groups
  • Government Procurement
  • Governments
  • Hormones
  • Medical Personnel
  • Musculoskeletal Physiology
  • Osteogenesis
  • Osteoporosis
  • Risk Factors
  • Sex Hormones
  • Women'S Health

Readers

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