Estrogen Metabolism and Prostate Cancer Risk

Abstract

Experimental evidence shows that estrogens are related to prostate cancer risk - In addition recent data suggest that 16 alpha hydroxilated estrogen metabolites, biologically strong estrogens, are associated with cancer risk, while Z-hydroxyisted metabolites, with lower estrogenic activity, are weakly related to this disease. This study analyzes the association of prostate cancer with estrogen metabolism in a population-based study conducted in Erie and Niagara Counties - (the Protein Study) - Data in 81 prostate cancer cases and 318 control subjects showed that a higher ratio of 2 hydroxyestrone to 16 alpha hydroxyestrone uses associated with a reduced risk of prostate cancer.

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Document Details

Document Type
Technical Report
Publication Date
Apr 01, 2001
Accession Number
ADB274630

Entities

People

  • Paola Muti

Organizations

  • University at Buffalo

Tags

DTIC Thesaurus Topics

  • Bone Fractures
  • Chemical Synthesis
  • Chemistry
  • Diseases And Disorders
  • Health
  • Health Care
  • Health Services
  • Mass Spectrometry
  • Medical Personnel
  • Musculoskeletal Physiology
  • Neoplasms
  • Papillomavirus Infections
  • Prostate Cancer
  • Public Health
  • Sex Hormones

Readers

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